Association between the TNFRII 196R allele and diagnosis of rheumatoid arthritis
Identifieur interne : 000C98 ( France/Analysis ); précédent : 000C97; suivant : 000C99Association between the TNFRII 196R allele and diagnosis of rheumatoid arthritis
Auteurs : Vincent Goëb [France] ; Philippe Dieudé [France] ; Olivier Vittecoq [France] ; Othmane Mejjad [France] ; Jean-François Ménard [France] ; Marlène Thomas [France] ; Danièle Gilbert [France] ; Patrick Boumier [France] ; Sophie Pouplin [France] ; Alain Daragon [France] ; Patrice Fardellone [France] ; François Tron [France] ; François Cornélis [France] ; Xavier Le Loët [France]Source :
- Arthritis Research & Therapy [ 1478-6354 ] ; 2005.
Abstract
Tumour necrosis factor (TNF)-α plays a key role in the pathogenesis of rheumatoid arthritis (RA). It binds to two receptors, namely TNF receptor (TNFR)I and TNFRII. Several studies have suggested an association between
Url:
DOI: 10.1186/ar1777
PubMed: 16207322
PubMed Central: 1257430
Affiliations:
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PMC:1257430Le document en format XML
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196R allele and diagnosis of rheumatoid arthritis</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association between the <italic>TNFRII </italic>
196R allele and diagnosis of rheumatoid arthritis</title>
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<author><name sortKey="Menard, Jean Francois" sort="Menard, Jean Francois" uniqKey="Menard J" first="Jean-François" last="Ménard">Jean-François Ménard</name>
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<placeName><settlement type="city">Rouen</settlement>
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<author><name sortKey="Thomas, Marlene" sort="Thomas, Marlene" uniqKey="Thomas M" first="Marlène" last="Thomas">Marlène Thomas</name>
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<country xml:lang="fr">France</country>
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<placeName><settlement type="city">Rouen</settlement>
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<author><name sortKey="Gilbert, Daniele" sort="Gilbert, Daniele" uniqKey="Gilbert D" first="Danièle" last="Gilbert">Danièle Gilbert</name>
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<placeName><settlement type="city">Rouen</settlement>
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<author><name sortKey="Boumier, Patrick" sort="Boumier, Patrick" uniqKey="Boumier P" first="Patrick" last="Boumier">Patrick Boumier</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Rheumatology Department, University Hospital of Amiens, Amiens</wicri:regionArea>
<placeName><settlement type="city">Amiens</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Pouplin, Sophie" sort="Pouplin, Sophie" uniqKey="Pouplin S" first="Sophie" last="Pouplin">Sophie Pouplin</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Rheumatology Department, University Hospital of Rouen, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Daragon, Alain" sort="Daragon, Alain" uniqKey="Daragon A" first="Alain" last="Daragon">Alain Daragon</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Rheumatology Department, University Hospital of Rouen, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Inserm U519, IFRMP 23, Faculty of Medicine, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
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<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Fardellone, Patrice" sort="Fardellone, Patrice" uniqKey="Fardellone P" first="Patrice" last="Fardellone">Patrice Fardellone</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Rheumatology Department, University Hospital of Amiens, Amiens</wicri:regionArea>
<placeName><settlement type="city">Amiens</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tron, Francois" sort="Tron, Francois" uniqKey="Tron F" first="François" last="Tron">François Tron</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Inserm U519, IFRMP 23, Faculty of Medicine, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U519, IFRMP 23, Faculty of Medicine, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Cornelis, Francois" sort="Cornelis, Francois" uniqKey="Cornelis F" first="François" last="Cornélis">François Cornélis</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>GenHotel, University of Evry-Paris VII, Faculty of Lariboisière-Saint Louis, Evry-Genopole and Unité de Génétique clinique, University Hospital of Lariboisière, APHP, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Loet, Xavier" sort="Le Loet, Xavier" uniqKey="Le Loet X" first="Xavier" last="Le Loët">Xavier Le Loët</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Rheumatology Department, University Hospital of Rouen, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Rheumatology Department, University Hospital of Rouen, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Inserm U519, IFRMP 23, Faculty of Medicine, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U519, IFRMP 23, Faculty of Medicine, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
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<series><title level="j">Arthritis Research & Therapy</title>
<idno type="ISSN">1478-6354</idno>
<idno type="eISSN">1478-6362</idno>
<imprint><date when="2005">2005</date>
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<front><div type="abstract" xml:lang="en"><p>Tumour necrosis factor (TNF)-α plays a key role in the pathogenesis of rheumatoid arthritis (RA). It binds to two receptors, namely TNF receptor (TNFR)I and TNFRII. Several studies have suggested an association between <italic>TNFRII </italic>
196R/R genotype and RA. The objective of the present study was to evaluate the predictive value of the <italic>TNFRII </italic>
196R allele for RA diagnosis and prognosis in a cohort of patients with very early arthritis. We followed up a total of 278 patients recruited from the community, who had swelling of at least two joints that had persisted for longer than 4 weeks but had been evolving for less than 6 months, and who had not received disease-modifying antirheumatic drugs or steroid therapy. At 2 years, patients were classified according to the American College of Rheumatology criteria. All patients were genotyped with respect to <italic>TNFRII </italic>
196M/R polymorphism. Radiographs of hands and feet (read according to the modified Sharp method) and the Health Assessment Questionnaire were used to quantify structural and functional severity. The cohort of 278 patients was found to include 156 and 122 RA and non-RA patients, respectively. The <italic>TNFRII </italic>
196R allele was found to be associated with RA (<italic>P </italic>
= 0.002). However, progression of radiographic severity and Health Assessment Questionnaire scores over 1 year did not differ between carriers of the 196R allele and noncarriers. Our findings suggest that the <italic>TNFRII </italic>
196R allele may be associated with RA diagnosis but that it does not predict early radiographic progression or functional severity in patients with very early, unclassified arthritis.</p>
</div>
</front>
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</settlement>
</list>
<tree><country name="France"><noRegion><name sortKey="Goeb, Vincent" sort="Goeb, Vincent" uniqKey="Goeb V" first="Vincent" last="Goëb">Vincent Goëb</name>
</noRegion>
<name sortKey="Boumier, Patrick" sort="Boumier, Patrick" uniqKey="Boumier P" first="Patrick" last="Boumier">Patrick Boumier</name>
<name sortKey="Cornelis, Francois" sort="Cornelis, Francois" uniqKey="Cornelis F" first="François" last="Cornélis">François Cornélis</name>
<name sortKey="Daragon, Alain" sort="Daragon, Alain" uniqKey="Daragon A" first="Alain" last="Daragon">Alain Daragon</name>
<name sortKey="Daragon, Alain" sort="Daragon, Alain" uniqKey="Daragon A" first="Alain" last="Daragon">Alain Daragon</name>
<name sortKey="Dieude, Philippe" sort="Dieude, Philippe" uniqKey="Dieude P" first="Philippe" last="Dieudé">Philippe Dieudé</name>
<name sortKey="Fardellone, Patrice" sort="Fardellone, Patrice" uniqKey="Fardellone P" first="Patrice" last="Fardellone">Patrice Fardellone</name>
<name sortKey="Gilbert, Daniele" sort="Gilbert, Daniele" uniqKey="Gilbert D" first="Danièle" last="Gilbert">Danièle Gilbert</name>
<name sortKey="Goeb, Vincent" sort="Goeb, Vincent" uniqKey="Goeb V" first="Vincent" last="Goëb">Vincent Goëb</name>
<name sortKey="Le Loet, Xavier" sort="Le Loet, Xavier" uniqKey="Le Loet X" first="Xavier" last="Le Loët">Xavier Le Loët</name>
<name sortKey="Le Loet, Xavier" sort="Le Loet, Xavier" uniqKey="Le Loet X" first="Xavier" last="Le Loët">Xavier Le Loët</name>
<name sortKey="Mejjad, Othmane" sort="Mejjad, Othmane" uniqKey="Mejjad O" first="Othmane" last="Mejjad">Othmane Mejjad</name>
<name sortKey="Menard, Jean Francois" sort="Menard, Jean Francois" uniqKey="Menard J" first="Jean-François" last="Ménard">Jean-François Ménard</name>
<name sortKey="Pouplin, Sophie" sort="Pouplin, Sophie" uniqKey="Pouplin S" first="Sophie" last="Pouplin">Sophie Pouplin</name>
<name sortKey="Thomas, Marlene" sort="Thomas, Marlene" uniqKey="Thomas M" first="Marlène" last="Thomas">Marlène Thomas</name>
<name sortKey="Tron, Francois" sort="Tron, Francois" uniqKey="Tron F" first="François" last="Tron">François Tron</name>
<name sortKey="Vittecoq, Olivier" sort="Vittecoq, Olivier" uniqKey="Vittecoq O" first="Olivier" last="Vittecoq">Olivier Vittecoq</name>
<name sortKey="Vittecoq, Olivier" sort="Vittecoq, Olivier" uniqKey="Vittecoq O" first="Olivier" last="Vittecoq">Olivier Vittecoq</name>
</country>
</tree>
</affiliations>
</record>
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